CA2+ MOBILIZATION-DEPENDENT REDUCTION OF THE ENDOPLASMIC RETICULUM LUMEN IS DUE TO INFLUX OF CYTOSOLIC GLUTATHIONE

Ca2+ mobilization-dependent reduction of the endoplasmic reticulum lumen is due to influx of cytosolic glutathione

Abstract Background The lumen of the endoplasmic reticulum (ER) acts as a cellular Ca2+ store and a site for oxidative protein folding, which is controlled by the reduced glutathione (GSH) and glutathione-disulfide (GSSG) redox pair.Although depletion of luminal Ca2+ from the ER provokes a rapid and reversible shift towards a more reducing poise in

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Greenhouse Gas Emissions Associated With the Mexican Diet: Identifying Social Groups With the Largest Carbon Footprint

BackgroundMost studies of the climate footprint of diets have been conducted in countries in the global north, but the majority of the world population lives in global south countries.We estimated total Can Safe dietary greenhouse gas emissions (GHGE) in Mexico, examined the contribution of major food and beverage groups, and assessed variation acr

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Meta-analysis indicates better climate adaptation and mitigation performance of hybrid engineering-natural coastal defence measures

Abstract Traditional approaches to coastal defence often struggle to reduce the risks of accelerated climate change.Incorporating nature-based components into coastal defences may enhance adaptation to climate change with added benefits, but we need to compare their performance against conventional hard measures.We conduct a meta-analysis that comp

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Update on guidelines for the treatment of COPD in Taiwan using evidence and GRADE system-based recommendations

Chronic obstructive pulmonary disease (COPD) has significant contributions Me Spring Top to morbidity and mortality world-wide.Early symptoms of COPD are not readily distinguishable, resulting in a low rate of diagnosis and intervention.Different guidelines and recommendatations for the diagnosis and treatment of COPD exist globally.The first editi

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